Research
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial
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* Corresponding author: Frederick M Ausubel ausubel@molbio.mgh.harvard.edu
1 Department of Molecular Biology, Massachusetts General Hospital, Cambridge Street, Boston, Massachusetts, 02114, USA
2 Department of Genetics, Harvard Medical School, Avenue Louis Pasteur, Boston, Massachusetts, 02115, USA
3 Current address: Microbia, Inc., Bent Street, Cambridge, Massachusetts, 02141, USA
4 Envivo Pharmaceuticals, Inc., Arsenal Street, Watertown, Massachusetts, 02472, USA
5 Department of Microbiology and Molecular Genetics, Harvard Medical School, Longwood Avenue, Boston, Massachusetts, 02115. USA
6 Department of Surgery, Massachusetts General Hospital, Fruit Street, Boston, Massachusetts, 02114, USA
7 Current address: Université de Montréal, Station Centre-ville, Montréal, H3C 3J7, Canada
8 Current address: INRS-Institut Armand-Frappier, boul. des Prairies, Laval, Quebec, H7V 1B7, Canada
9 Current address: Cubist Pharmaceuticals, Inc., Hayden Avenue, Lexington, Massachusetts, 02421, USA
10 Harvard Medical School - Partners Healthcare Center for Genetics and Genomics, Landsdowne Street, Cambridge, Massachusetts, 02139, USA
11 Current address: Core Facilities, Cornell University, Thurston Avenue, Ithaca, New York, 14850, USA
Genome Biology 2006, 7:R90 doi:10.1186/gb-2006-7-10-r90
Published: 12 October 2006Additional files
Additional data file 1:
Summary of supplementary methods.
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Additional data file 2:
A table of PA14 gene annotations.
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Additional data file 3:
The percentage of PA14 and PAO1 genes corresponding to each of 28 functional categories (shown for both the whole genome and strain-specific genes as described in Additional data file 4).
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Additional data file 4:
Summary of properties of PA14-specific and PAO1-specific regions.
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Additional data file 5:
Properties of oligos found on the genotyping microarray.
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Additional data file 6:
Microarray genotyping data for the 20 strains examined in this study (normalized average data and log2 ratio of normalized averages).
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Additional data file 7:
Coordinates of regions in PA14 or PAO1 that are common to four sequenced P. aeruginosa strains (PA14, PAO1, and two CF isolates: 2192 and C3719) and therefore comprise a putative P. aeruginosa core genome.
Format: XLS Size: 47KB Download file
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