Genome Biology

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Open Access Research

Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs

Maria F Cardone1, Alicia Alonso2, Michele Pazienza1, Mario Ventura1, Gabriella Montemurro1, Lucia Carbone1, Pieter J de Jong3, Roscoe Stanyon4, Pietro D'Addabbo1, Nicoletta Archidiacono1, Xinwei She5, Evan E Eichler5, Peter E Warburton2 and Mariano Rocchi1*

Author Affiliations

1 Department of Genetics and Microbiology, University of Bari, Bari, Italy

2 Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA

3 Children's Hospital Oakland Research Institute, Oakland, California 94609, USA

4 Department of Animal Biology and Genetics 'Leo Pardi', University of Florence, Florence, Italy

5 Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA

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Genome Biology 2006, 7:R91 doi:10.1186/gb-2006-7-10-r91

Published: 13 October 2006

Additional files

Additional data file 1:

Non-primate mammalian BAC clones utilized in the study, and overgo probes used to screen them

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Additional data file 2:

The legend for this Figure is in 3

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Additional data file 3:

Legend to the figure in 2

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Additional data file 4:

RefSeq genes with sequence similarity to 13q21duplicated regions

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Additional data file 5:

Segmental duplications (80% to 90% sequence identity and >1 kb or 250 bp) from a 11 Mb region (61 Mb to 72 Mb) of 13q21 to other regions of the genome

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Additional data file 6:

Legend to the figure in 5

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Additional data file 7:

Specifications of the custom made genomic BAC array (Array design)

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Additional data file 8:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 294KB Download file

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Additional data file 9:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 1.1MB Download file

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Additional data file 10:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 510KB Download file

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Additional data file 11:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 612KB Download file

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Additional data file 12:

Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 272KB Download file

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Additional data file 13:

Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 1MB Download file

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Additional data file 14:

Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 1MB Download file

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Additional data file 15:

Text: Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 1023KB Download file

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Additional data file 16:

Data for control CENP-A and CENP-C ChIP performed on a cell line containing a 13q32 neocentromere (cell line BBB)

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Additional data file 17:

Data for control CENP-A and CENP-C ChIP performed on a cell line containing a 13q32 neocentromere (cell line BBB)

Format: XLS Size: 1.2MB Download file

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