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Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs

Maria Francesca Cardone1 email, Alicia Alonso2 email, Michele Pazienza1 email, Mario Ventura1 email, Gabriella Montemurro1 email, Lucia Carbone1 email, Pieter J de Jong3 email, Roscoe Stanyon4 email, Pietro D'Addabbo1 email, Nicoletta Archidiacono1 email, Xinwei She5 email, Evan E Eichler5 email, Peter E Warburton2 email and Mariano Rocchi1 email

1Department of Genetics and Microbiology, University of Bari, Bari, Italy

2Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA

3Children's Hospital Oakland Research Institute, Oakland, California 94609, USA

4Department of Animal Biology and Genetics 'Leo Pardi', University of Florence, Florence, Italy

5Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA

author email corresponding author email

Genome Biology 2006, 7:R91doi:10.1186/gb-2006-7-10-r91

Published: 13 October 2006

Subject areas: Evolution, Genetics


Additional files

Additional data file 1:

Non-primate mammalian BAC clones utilized in the study, and overgo probes used to screen them

Format: DOC Size: 77KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional data file 2:

The legend for this Figure is in 3

Format: EPS Size: 1.3MB Download file

Additional data file 3:

Legend to the figure in 2

Format: DOC Size: 22KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional data file 4:

RefSeq genes with sequence similarity to 13q21duplicated regions

Format: XLS Size: 24KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 5:

Segmental duplications (80% to 90% sequence identity and >1 kb or 250 bp) from a 11 Mb region (61 Mb to 72 Mb) of 13q21 to other regions of the genome

Format: EPS Size: 2.2MB Download file

Additional data file 6:

Legend to the figure in 5

Format: DOC Size: 43KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional data file 7:

Specifications of the custom made genomic BAC array (Array design)

Format: XLS Size: 152KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 8:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 294KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 9:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 1.2MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 10:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 510KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 11:

Primary data for three independent CenpA ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the invdup13q14 neocentric chromosome (cell line CHOP13)

Format: XLS Size: 612KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 12:

Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 272KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 13:

Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 14:

Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 15:

Text: Primary data for three independent CenpC ChIP on a CHIP experiments and combined data for the three biological replicates for the cell line containing the ring13q21 neocentric chromosome (cell line Ring A)

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 16:

Data for control CENP-A and CENP-C ChIP performed on a cell line containing a 13q32 neocentromere (cell line BBB)

Format: XLS Size: 1.1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 17:

Data for control CENP-A and CENP-C ChIP performed on a cell line containing a 13q32 neocentromere (cell line BBB)

Format: XLS Size: 1.2MB Download file

This file can be viewed with: Microsoft Excel Viewer

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