Genome Biology

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Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues

Yan Zhang, Hector Romero, Gustavo Salinas and Vadim N Gladyshev*

Genome Biology 2006, 7:R94 doi:10.1186/gb-2006-7-10-r94

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BioMed Central: 4 citations

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Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization

Yan Zhang, Dmitry A Rodionov, Mikhail S Gelfand, Vadim N Gladyshev BMC Genomics 2009, 10:78 (10 February 2009)

Research article   Open Access

In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait

Yan Zhang, Anton A Turanov, Dolph L Hatfield, Vadim N Gladyshev BMC Genomics 2008, 9:251 (29 May 2008)

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Reduced reliance on the trace element selenium during evolution of mammals

Alexey V Lobanov, Dolph L Hatfield, Vadim N Gladyshev Genome Biology 2008, 9:R62 (31 March 2008)

Evolution from fish to mammals was accompanied by decreased use of selenocysteine, raising questions about the need for selenium dietary supplements when pathology is not imminent.

Research   Open Access

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life

Alexey V Lobanov, Dmitri E Fomenko, Yan Zhang, Aniruddha Sengupta, Dolph L Hatfield, Vadim N Gladyshev Genome Biology 2007, 8:R198 (19 September 2007)

In silico and metabolic labeling studies of the selenoproteomes of several eukaryotes revealed distinct selenoprotein patterns as well as an ancient origin of selenoproteins and massive, independent losses in land plants, fungi, nematodes, insects and some protists, suggesting that the environment plays an important role in selenoproteome evolution.