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Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues

Yan Zhang1, Hector Romero2, Gustavo Salinas3 and Vadim N Gladyshev1*

Author Affiliations

1 Department of Biochemistry, University of Nebraska, 1901 Vine street, Lincoln, NE 68588-0664, USA

2 Laboratorio de Organización y Evolución del Genoma, Laboratorio de Organización y Evolución del Genoma, Dpto de Biología Celular y Molecular, Instituto de Biología, Facultad de Ciencias, Iguá 4225, Montevideo, CP 11400, Uruguay

3 Cátedra de Inmunología, Facultad de Química/Ciencias, Instituto de Higiene, Avda A Navarro 3051, Montevideo, CP 11600, Uruguay

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Genome Biology 2006, 7:R94  doi:10.1186/gb-2006-7-10-r94

Published: 20 October 2006

Additional files

Additional data file 1:

Table S1 contains data on distribution of selenoproteins and their Cys-containing homologs in different organisms. Table S2 includes the complete list of sister and more distant species of selenoprotein-containing bacteria. Table S3 contains information about selenoprotein loss events identified in 25 bacterial selenoprotein families. Tables S4 and S5 show the distribution of organisms, which have or lack selenium utilization traits as analyzed by considering different environmental factors. Tables S6 and S7 show the distribution of organisms, which have or lack Sec-/Cys-containing form of peroxiredoxin, and HesB-like protein as analyzed by considering oxygen requirement.

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Open Data

Additional data file 2:

Figure S1 shows phylograms of SelA, SelB, SelD, and YbbB sequences. Figures S2 and S3 show the distribution of selenoproteins and their Cys-containing homologs in different organisms.

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Open Data

Additional data file 3:

Sequences of components of selenium utilization traits (SelA, SelB, SelD and YbbB) in bacteria. Sec is represented by U

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Open Data

Additional data file 4:

Sequences of all 285 selenoproteins (25 families) in bacteria. Sec is represented by U

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Open Data