Table 1

Distribution and Sec evolutionary trends of 25 bacterial selenoprotein families
Selenoprotein family
 Number of selenoproteins
 Sec/Cys conversion events
 Selenoprotein loss events





Sec→Cys
 Cys→Sec
Formate dehydrogenase alpha subunit (FdhA)
 103
 7
 -
 2
Selenophosphate synthetase (SelD)
 38
 3
 -
 6
Coenzyme F420-reducing hydrogenase delta subunit (FrhD)a
 19
 3
 3
 5
Heterodisulfide reductase, subunit A (HdrA)a
 16
 -
 2
 4
Peroxiredoxin (Prx)a
 12
 -
 5
 -
HesB-like
 11
 2
 -
 3
Glycine reductase selenoprotein A (GrdA)
 11
 -
 -
 4
Glycine reductase selenoprotein B (GrdB)a
 11
 -
 -
 6
SelW-likea
 10
 -
 -
 3
Prx-like thiol:disulfide oxidoreductasea
 8
 -
 3
 -
Thioredoxin (Trx)a
 7
 -
 -
 -
Coenzyme F420-reducing hydrogenase α subunit (FrhA)a
 6
 -
 2
 -
Fe-S oxidoreductase (GlpC)
 5
 -
 2
 -
Proline reductase (PR)a
 5
 -
 -
 -
DsbA-likea
 4
 -
 1
 1
Glutaredoxin (Grx)a
 3
 -
 3
 -
Thiol:disulfide interchange proteina
 3
 -
 1
 -
AhpD-like (COG2128)a
 2
 -
 2
 -
ArsC-likea
 2
 -
 1
 2
DsbG-likea
 2
 -
 2
 -
Distant AhpD homologa
 2
 -
 1
 -
Homolog of AhpF, amino-terminal domaina
 2
 -
 2
 1
DsrE-likea
 1
 -
 1
 -
NADH oxidase
 1
 -
 1
 1
Glutathione peroxidase (GPx)a
 1
 -
 1
 -
Total
 285
 15
 33
 38

aHomologs of thiol-based oxidoreductases.

Zhang et al. Genome Biology 2006 7:R94   doi:10.1186/gb-2006-7-10-r94