Table 1

Distribution and Sec evolutionary trends of 25 bacterial selenoprotein families

Selenoprotein family

Number of selenoproteins

Sec/Cys conversion events

Selenoprotein loss events

Sec→Cys

Cys→Sec

Formate dehydrogenase alpha subunit (FdhA)

103

7

-

2

Selenophosphate synthetase (SelD)

38

3

-

6

Coenzyme F420-reducing hydrogenase delta subunit (FrhD)^a

19

3

3

5

Heterodisulfide reductase, subunit A (HdrA)^a

16

-

2

4

Peroxiredoxin (Prx)^a

12

-

5

-

HesB-like

11

2

-

3

Glycine reductase selenoprotein A (GrdA)

11

-

-

4

Glycine reductase selenoprotein B (GrdB)^a

11

-

-

6

SelW-like^a

10

-

-

3

Prx-like thiol:disulfide oxidoreductase^a

8

-

3

-

Thioredoxin (Trx)^a

7

-

-

-

Coenzyme F420-reducing hydrogenase α subunit (FrhA)^a

6

-

2

-

Fe-S oxidoreductase (GlpC)

5

-

2

-

Proline reductase (PR)^a

5

-

-

-

DsbA-like^a

4

-

1

1

Glutaredoxin (Grx)^a

3

-

3

-

Thiol:disulfide interchange protein^a

3

-

1

-

AhpD-like (COG2128)^a

2

-

2

-

ArsC-like^a

2

-

1

2

DsbG-like^a

2

-

2

-

Distant AhpD homolog^a

2

-

1

-

Homolog of AhpF, amino-terminal domain^a

2

-

2

1

DsrE-like^a

1

-

1

-

NADH oxidase

1

-

1

1

Glutathione peroxidase (GPx)^a

1

-

1

-

Total

285

15

33

38

^aHomologs of thiol-based oxidoreductases.

Zhang et al. Genome Biology 2006 7:R94   doi:10.1186/gb-2006-7-10-r94