Genome Biology
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OpinionHow complete are current yeast and human protein-interaction networks?G Traver Hart1, Arun K Ramani1,2 and Edward M Marcotte1  1
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA 2
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK  author email corresponding author email
Genome Biology 2006,
7:120doi:10.1186/gb-2006-7-11-120
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| Published: |
1 December 2006 |
Subject areas: Bioinformatics, Genome studies, Model organisms, Methods, Molecular biology Abstract
We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions. | 
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