Table 1

Yeast protein-interaction assay false-positive rates: yeast datasets

Dataset
Number of interactions
Derived false-positive rate* (%)
Published false-positive rate (%)
Average false-positive rate (%)

Uetz et al. [35]
854
46 [32]
32 [24],47 [44], 50 [37], 51 [42]
45
Ito [36]
4,393
89 [32]
71 [24], 78 [41], 85 [37], 91 [44]
83
Gavin et al. [16]
3,180
68 [32]
14 [24], 22 [4], <72 (upper bound [20])
35
Ho et al. [17]
3,618
83 [32], 81, 82, 80
55 [24], <97 (upper bound [20])
76
Jansen et al. [22]
15,922
81, 79
-
80
Gavin et al. [27]
18,137
78, 82, 86
-
82
Krogan et al. [28]
14,317 (7,123 core)
75, 79, 66(59, 65, 37core)
-
73 (54 core)
Overall
51,419


72

*This interaction assay false-positive rate is taken from D'haeseleer and Church [32] or derived using the method therein. Multiple values derive from choosing either the GRID [2] or MIPS [33] reference sets. This interaction assay false-positive rate is calculated with the EPR server of Deane et al. [42]. The mean of four values estimated from Table S3 of Lee et al. [24] by fitting the interaction set as a linear combination of true-positive (small scale interactions) and false-positive (random pairs) interactions.

Hart et al. Genome Biology 2006 7:120   doi:10.1186/gb-2006-7-11-120