Influence of pw-score cutoff on accuracy of predictions. A pw-score close to 1 indicates a promiscuous domain pair that can obtain a high LP-score independent of the topology of the underlying protein-protein interaction network, and does not have significant witness support. Higher LP-score cutoffs lead to higher prediction accuracy; smaller (more stringent) pw-score cutoffs help improve it further.
Guimarães et al. Genome Biology 2006 7:R104 doi:10.1186/gb-2006-7-11-r104