PPV versus sensitivity in enrichment of confirmed interactions experiment. Comparison of PPV (TP/(TP + FP)) and Sensitivity (TP/(TP + FN)) attained by the PE method with pw-score cutoffs of 0.01 and 0.05, and previously by the Association, EM, and DPEA methods. The comparison is based on estimations of how many of the high-scoring domain-domain interactions are confirmed by the gold standard set.
Guimarães et al. Genome Biology 2006 7:R104 doi:10.1186/gb-2006-7-11-r104