Comparison of codon enrichment correlation (CEC) distributions. (a) Histogram of CEC for all ORFs listed in Ghaemmaghami et al. , for all ORFs seen in PeptideAtlas (PA), and for all ORFs not seen in PeptideAtlas; and (b) histogram of CEC for ORFs not seen in the Ghaemmaghami et al. expression sets and for all ORFs not seen in PeptideAtlas. Observed proteins in PeptideAtlas and in Ghaemmaghami et al. show a positive skew in CEC showing that they deviate significantly from that expected from a random sequence of codons, while the unobserved proteins show more uniformly distributed CEC values.
King et al. Genome Biology 2006 7:R106 doi:10.1186/gb-2006-7-11-r106