Small subnetwork identified for the shift from glucose to ethanol as carbon source. Genes marked red are upregulated and genes marked green are downregulated upon the shift. The metabolic map is simplified (many transport reactions are not included and the two steps of the glycoxylate pathway [encoded by the genes acuD and acuE] are placed in the mitochondria even though they are really located in the glyoxysomes). Conversions that involve several steps are indicated by dashed arrows. The metabolites are as follows: ACCOA, acetyl-CoA; ACE, acetate; ACHO, acetaldehyde; CIT, citrate; F16BP, fructose 1,6-bisphosphate; F6P, fructose 6-phosphate; G6P, glucose 6-phosphate; GLY, glyoxylate; ICIT, isocitrate; MAL, malate; OAA, oxaloacetate; PEP, phosphoenolpyruvate; PYR, pyruvate; SUC, succinate.
David et al. Genome Biology 2006 7:R108 doi:10.1186/gb-2006-7-11-r108