Table 5 |
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Enzymes and transporters in subnetworks |
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Ethanol versus glucose (26 reactions) |
Ethanol versus glycerol (33 reactions) |
Glycerol versus glucose (34 reactions) |
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6-Phosphofructokinase |
1,3-β-Glucan synthase |
5'-Phosphoribosylformyl glycinamidine synthetase |
|
Acetyl-CoA hydrolase |
Acetyl-CoA hydrolase |
8-Amino-7-oxononanoate synthase |
|
Aconitate hydratase (mitochondrial) |
Acetyl-CoA synthase |
Aldehyde dehydrogenase |
|
Alcohol dehydrogenase |
Aconitate hydratase (mitochondrial) |
α,α-Trehalase |
|
Aldehyde dehydrogenase |
Adenylate kinase |
α-Glucosidase |
|
α-Glucosidase |
Alanine-glyoxylate transaminase |
α-Glucosidase |
|
α-Glucosidase |
Alcohol dehydrogenase |
Aspartate-carbamoyltransferase |
|
α-Glucosidase |
Aldehyde dehydrogenase |
Aspartate-carbamoyltransferase |
|
Aspartate transaminase (mitochondrial) |
Aspartate transaminase (mitochondrial) |
B-ketoacyl-ACP synthase |
|
Aspartate transaminase (mitochondrial) |
Aspartate transaminase (mitochondrial) |
Carbamoyl-phophate synthetase |
|
ATP:citrate oxaloacetate-lyase |
ATP:citrate oxaloacetate-lyase |
Citrate synthase (mitochondrial) |
|
Carnitine O-acetyltransferase |
Carnitine O-acetyltransferase |
Dihydrolipoamide S-acetyltransferase (mitochondrial) |
|
Carnitine O-acetyltransferase (mitochondrial) |
Carnitine O-acetyltransferase (mitochondrial) |
Dihydroxy acid dehydratase (mitochondrial) |
|
Carnitine/acyl carnitine carrier |
Citrate synthase (mitochondrial) |
Fatty-acyl-CoA synthase |
|
Citrate synthase (mitochondrial) |
Citrate synthase (mitochondrial) |
Fatty-acyl-CoA synthase |
|
Formate dehydrogenase |
Formate dehydrogenase |
Fructose-bisphosphatase |
|
Fructose-bisphosphatase |
Fumarate dehydratase (mitochondrial) |
Glucan 1,3-β-glucosidase (extracellular) |
|
Gluconolactonase (extracellular) |
Glucose 6-phosphate 1-dehydrogenase |
Glucose 6-phosphate 1-dehydrogenase |
|
Glucose 6-phosphate 1-dehydrogenase |
Glucose-6-phosphate isomerase |
Glycerol 3-phosphate dehydrogenase (FAD dependent) |
|
Glyceraldehyde 3-phosphate dehydrogenase |
Glycerol 3-phosphate dehydrogenase (FAD dependent) |
Glycerol dehydrogenase |
|
Isocitrate lyase (glyoxysomal) |
Glycerol dehydrogenase |
Glycerol kinase |
|
Glycerol kinase |
Isocitrate lyase (glyoxysomal) |
GTP cyclohydrolase I |
|
Mannose-6-phosphate isomerase |
Malate dehydrogenase (malic enzyme; NADP+) |
Ketol-acid reductoisomerase (mitochondrial) |
|
Phosphoenolpyruvate carboxykinase |
Malate synthase (glyoxysomal) |
Malate dehydrogenase (malic enzyme; NADP+) |
|
Pyruvate kinase |
Mannitol 2-dehydrogenase (NAD+) |
Mannitol 2-dehydrogenase (NAD+) |
|
Transketolase |
Phosphoenolpyruvate carboxykinase |
Mannitol 2-dehydrogenase (NADP+) |
|
Phosphoglucomutase |
Phosphoenolpyruvate carboxykinase |
|
|
Phosphogluconate dehydrogenase (decarboxylating) |
Phosphoribosylamine-glycine ligase |
|
|
Phosphorylase |
Phosphorylase |
|
|
Pyruvate kinase |
Pyruvate dehydrogenase (lipoamide) (mitochondrial) |
|
|
Transketolase |
Pyruvate kinase |
|
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UTP-glucose-1-phosphate uridylyltransferase |
Ribulokinase |
|
|
UTP-glucose-1-phosphate uridylyltransferase |
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Shown is a list of the enzymes and transporters that participate in the 'small', highly correlated subnetworks for each pair-wise comparison between the three carbon sources investigated. Enzymes common to all reactions are highlighted in bold. Some enzymes appear more than once in the table, which means that they are isoenzymes and are encoded by different genes. CoA, coenzyme A. |
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David et al. Genome Biology 2006 7:R108 doi:10.1186/gb-2006-7-11-r108 |
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