Table 2 |
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|
Summary of DAVID Gene Ontology classification of target mRNA populations |
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|
Cellular function |
Gene Ontology group |
U2AF (%) |
PTB (%) |
|
|
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|
Gene expression |
Transcription, DNA-dependent |
13.1 |
10.6 |
|
Transcription from Pol II promoter |
3.8 |
3.1 |
|
|
Negative regulation of transcription from Pol II promoter |
0.7 |
- |
|
|
DNA packaging |
1.4 |
- |
|
|
Nuclear mRNA splicing, via spliceosome |
1.2 |
- |
|
|
Translation |
1.1 |
- |
|
|
Cell cycle |
Cell proliferation |
6.5 |
5.6 |
|
Cell cycle |
4.9 |
4.1 |
|
|
Regulation of cell cycle |
3 |
2.3 |
|
|
G1/S transition of mitotic cell cycle |
0.6 |
- |
|
|
Mitotic cell cycle |
1.3 |
- |
|
|
Apoptosis |
Death |
- |
3 |
|
Apoptosis |
- |
2.8 |
|
|
Negative regulation of apoptosis |
0.9 |
||
|
Ubiquitination |
Ubiquitin cycle |
4.9 |
4.5 |
|
Protein ubiquitination |
2.6 |
2.1 |
|
|
Signaling |
Intracellular signaling cascade |
6 |
6.8 |
|
Small GTPase mediated signal transduction |
1.9 |
2.6 |
|
|
Intracellular transport and vesicles |
Establishment of localization |
- |
10.4 |
|
Endosome organization and biogenesis |
- |
0.4 |
|
|
Endosome transport |
- |
0.3 |
|
|
Vesicle-mediated transport |
- |
2.1 |
|
|
|
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|
In the U2AF and PTB columns, '-' indicates that enrichment was not significant relative to the proportion of array genes belonging to the Gene Ontology group (P > 0.001). PTB, polypyrimidine tract binding protein; U2AF, U2 small nuclear RNP auxiliary factor. |
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Gama-Carvalho et al. Genome Biology 2006 7:R113 doi:10.1186/gb-2006-7-11-r113 |
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