Genome Biology

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Is mammalian chromosomal evolution driven by regions of genome fragility?

Aurora Ruiz-Herrera, Jose Castresana and Terence J Robinson*

Genome Biology 2006, 7:R115 doi:10.1186/gb-2006-7-12-r115

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Comparative genomics reveals birth and death of fragile regions in mammalian evolution

Max A Alekseyev, Pavel A Pevzner Genome Biology 2010, 11:R117 (30 November 2010)

A new model explains the frequencies of breakpoints at genomic rearrangement hotspots by demonstrating that fragile sites undergo birth and death.

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Long-range regulation is a major driving force in maintaining genome integrity

Emmanuel Mongin, Ken Dewar, Mathieu Blanchette BMC Evolutionary Biology 2009, 9:203 (15 August 2009)

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Distinct retroelement classes define evolutionary breakpoints demarcating sites of evolutionary novelty

Mark S Longo, Dawn M Carone, Eric D Green, Michael J O'Neill, Rachel J O'Neill BMC Genomics 2009, 10:334 (24 July 2009)

An evolutionary breakpoint in the tamar wallaby, and an orthologous breakpoint found in human cancers, resemble centromeric regions in being enriched in LINE1s and ERVs and short of SINEs, a pattern of retroelements that may predispose to genomic instability

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The where and wherefore of evolutionary breakpoints

David Sankoff Journal of Biology 2009, 8:66 (24 July 2009)

David Sankoff discusses the properties of chromatin in breakpoint regions and their relevance to evolutionary change in the light of two recent papers in BMC Genomics.

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Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution

Claus Kemkemer, Matthias Kohn, David N Cooper, Lutz Froenicke, Josef Högel, Horst Hameister, Hildegard Kehrer-Sawatzki BMC Evolutionary Biology 2009, 9:84 (24 April 2009)

This article is part of a collection on Bovine: the companion...

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Chromosomal instability in Afrotheria: fragile sites, evolutionary breakpoints and phylogenetic inference from genome sequence assemblies

Aurora Ruiz-Herrera, Terence J Robinson BMC Evolutionary Biology 2007, 7:199 (24 October 2007)