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Is mammalian chromosomal evolution driven by regions of genome fragility?

Aurora Ruiz-Herrera1, Jose Castresana2 and Terence J Robinson1*

Author Affiliations

1 Evolutionary Genomics Group, Department of Botany & Zoology, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa

2 Institut de Biologia Molecular de Barcelona, CSIC, Department of Physiology and Molecular Biodiversity, Jordi Girona 18, 08034 Barcelona, Spain

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Genome Biology 2006, 7:R115  doi:10.1186/gb-2006-7-12-r115

Published: 8 December 2006

Additional files

Additional data file 1:

Multispecies alignments to all human chromosomes.

Format: PDF Size: 144KB Download file

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Open Data

Additional data file 2:

Distribution of base pair tandem repeats along all human chromosomes represented as windows of 250,000 bp each.

Format: PDF Size: 184KB Download file

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Open Data

Additional data file 3:

Base pairs implicated in tandem repeats per chromosome.

Format: PDF Size: 134KB Download file

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Open Data

Additional data file 4:

List of all of the homologous syntenic blocks (HSB) detected.

Format: PDF Size: 179KB Download file

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Open Data

Additional data file 5:

List of evolutionary breakpoint regions (EBR) less than 4 Mb and their chromosomal positions in the human genome.

Format: PDF Size: 133KB Download file

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Open Data

Additional data file 6:

List of evolutionary chromosomal bands detected.

Format: PDF Size: 108KB Download file

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Open Data

Additional data file 7:

List of all human fragile sites described in the literature.

Format: PDF Size: 86KB Download file

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Open Data

Additional data file 8:

List of common human fragile sites that have been cloned and analyzed at the molecular level.

Format: PDF Size: 123KB Download file

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Open Data

Additional data file 9:

Human genome divided into windows of 0.250 Mb.

Format: PDF Size: 387KB Download file

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Open Data