Figure 5.

Typical kidney tumor as found in p53^E241X/E241X homozygous fish. (a) A stereoscopic view of the kidney tumor identified in a 2.5 month old homozygous p53^E241X/E241X fish. (b-d) Hematoxylin-eosin staining of normal (b) and neoplastic (c) kidney of medaka. Note that the interstitial tissue is infiltrated with numerous hematopoietic cells destroying the normal architecture of renal tubules. The higher magnification shows the mixture of small lymphocytes with little cytoplasm and the plasmacyte-like cells with large basophilic cytoplasm (d).