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Gene function and expression level influence the insertion/fixation dynamics of distinct transposon families in mammalian introns

Manuela Sironi1, Giorgia Menozzi1, Giacomo P Comi2, Matteo Cereda1, Rachele Cagliani1, Nereo Bresolin12 and Uberto Pozzoli1*

Author Affiliations

1 Scientific Institute IRCCS E Medea, Bioinformatic Lab, Via don L Monza, 23842 Bosisio Parini (LC), Italy

2 Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, 20100 Milan, Italy

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Genome Biology 2006, 7:R120  doi:10.1186/gb-2006-7-12-r120

Published: 20 December 2006

Additional files

Additional data file 1:

Supplementary text presenting analysis of MCS density and TE integration frequency over evolutionary time. A supplementary figure describing the results is also provided (supplementary Figure 1) together with its legend.

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Additional data file 2:

Supplementary Table 1 lists GO terms associated with mouse TE-poor genes. Supplementary Figure 2 shows analysis of murine MIR sequences associated with immune response genes. Supplementary Figure 3 shows gene-expression dependent variation in TE intronic abundance for human genes (SAGE data). Supplementary Figure 4 shows gene-expression dependent variation in TE intronic abundance for mouse genes (microarray data). Supplementary Figure 5 shows gene-expression dependent variation in TE intronic abundance for mouse genes (SAGE data). Supplementary Figure 6 shows intronic to intergenic relative frequency difference (calculated on gene flanks rather than entire intergenic regions).

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Open Data