Table 1 |
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|
DDI-PPI mapping: all protein interactions |
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|
Organisma |
E. coli |
yeast |
worm |
fly |
human |
|
|
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|
Number of PPIsb |
6,934 |
24,699 |
5,315 |
24,703 |
28,800 |
|
Number of PPIs with known domainsc (N) |
6,038 |
18,202 |
3,351 |
14,939 |
25,004 |
|
Number of PPIs to which DDIs could be mappedd (n) (%; n/N*100) Median value of random networks (P value) |
806 (13%) 295 (<0.001) |
1,660 (9%) 363 (<0.001) |
375 (11%) 142 (<0.001) |
891 (6%) 276 (<0.001) |
4,924 (20%) 911 (<0.001) |
|
No. of PPIs to which DDIs could be mapped, disregarding PPI-DDI mappings due to overlap between the structural database and the PPI data (n)(%; n/N*100) Median value of random networks (P value) |
755 (13%) 288 (<0.001) |
1608 (9%) 353 (<0.001) |
375 (11%) 142 (<0.001) |
889 (6%) 276 (<0.001) |
3,989 (16%) 856 (<0.001) |
|
|
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|
aOrganism labeling: yeast, S. cerevisiae; worm, C. elegans; fly, D. melanogaster. bSee Figure 1a. cSee Figure 1c. dSee Figure 1e. DDI, domain-domain interaction; PPI, protein-protein interaction. |
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|
Itzhaki et al. Genome Biology 2006 7:R125 doi:10.1186/gb-2006-7-12-r125 |
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