Table 1

DDI-PPI mapping: all protein interactions

Organisma

E. coli

yeast

worm

fly

human


Number of PPIsb

6,934

24,699

5,315

24,703

28,800

Number of PPIs with known domainsc (N)

6,038

18,202

3,351

14,939

25,004

Number of PPIs to which DDIs could be mappedd (n) (%; n/N*100)

Median value of random networks (P value)

806 (13%)

295 (<0.001)

1,660 (9%)

363 (<0.001)

375 (11%)

142 (<0.001)

891 (6%)

276 (<0.001)

4,924 (20%)

911 (<0.001)

No. of PPIs to which DDIs could be mapped, disregarding PPI-DDI mappings due to overlap between the structural database and the PPI data (n)(%; n/N*100)

Median value of random networks (P value)

755 (13%) 288 (<0.001)

1608 (9%)

353 (<0.001)

375 (11%)

142 (<0.001)

889 (6%)

276 (<0.001)

3,989 (16%)

856 (<0.001)


aOrganism labeling: yeast, S. cerevisiae; worm, C. elegans; fly, D. melanogaster. bSee Figure 1a. cSee Figure 1c. dSee Figure 1e. DDI, domain-domain interaction; PPI, protein-protein interaction.

Itzhaki et al. Genome Biology 2006 7:R125   doi:10.1186/gb-2006-7-12-r125

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