Table 2

DDI-PPI mapping: interactions involving only single-domain proteins

Organisma

E. coli

yeast

worm

fly

human


Number of PPIs (with known domains) (N)

497

2,418

335

2,068

1,633

Number of PPIs to which DDIs could be mapped (n) (%; n/N*100)

Median value of random networks (P value)

117 (24%)

92 (0.005)

284 (12%)

79 (<0.001)

60 (18%)

38 (<0.001)

217 (10%)

55 (<0.001)

400 (25%)

135 (<0.001)


a Organism labeling: yeast: S. cerevisiae, worm: C. elegans, fly: D. melanogaster. For the analysis of each organism, DDIs in the structural database that are based on single-domain proteins of the respective organism were excluded. DDI, domain-domain interaction; PPI, protein-protein interaction.

Itzhaki et al. Genome Biology 2006 7:R125   doi:10.1186/gb-2006-7-12-r125

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