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DDI-PPI mapping: interactions involving only single-domain proteins |
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| Organisma |
E. coli |
yeast |
worm |
fly |
human |
|
|
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| Number of PPIs (with known domains) (N) |
497 |
2,418 |
335 |
2,068 |
1,633 |
| Number of PPIs to which DDIs could be mapped (n) (%; n/N*100) Median value of random networks (P value) |
117 (24%) 92 (0.005) |
284 (12%) 79 (<0.001) |
60 (18%) 38 (<0.001) |
217 (10%) 55 (<0.001) |
400 (25%) 135 (<0.001) |
|
a Organism labeling: yeast: S. cerevisiae, worm: C. elegans, fly: D. melanogaster. For the analysis of each organism, DDIs in the structural database that are based on single-domain proteins of the respective organism were excluded. DDI, domain-domain interaction; PPI, protein-protein interaction. | |||||
Itzhaki et al. Genome Biology 2006 7:R125 doi:10.1186/gb-2006-7-12-r125 |
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