Table 4

DDI-PPI mapping based on both single domain PPIs and the structural DDIs

Organisma

E. coli

yeast

worm

fly

human


Number of PPIs

6,934

24,699

5,315

24,703

28,800

Number of PPIs with known domains (N)

6,038

18,202

3,351

14,939

25,004

Number of PPIs to which DDIs could be mapped (n) (%; n/N*100)

1,234 (20%)

5,048 (28%)

860 (26%)

3,983 (27%)

7,991 (32%)


a Organism labeling: yeast: S. cerevisiae, worm: C. elegans, fly: D. melanogaster. DDI, domain-domain interaction; PPI, protein-protein interaction.

Itzhaki et al. Genome Biology 2006 7:R125   doi:10.1186/gb-2006-7-12-r125

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