Table 2

P. falciparum gene families encoding exported proteins

Family

Paralogs

Transmembrane domains

Exons

Microarray data

Comments


R

T

S

M

Sp

G


PfEMP1

59

1

2

x

x

x

x

x

x

DnaJ I

3

0

1/4/5

1

0

0

1

0

0

DnaJ domains 1-3

DnaJ III

16

0/1

2

3

1

1

3

0

0

DnaJ domain 1

EMP3

2

0

2

2

2

1

2

1

0

MC proteins

GBP130

3

0

2

2

2

2

1

1

0

RBC surface proteins

FIKK kinases

20

0

3

4

4

0

4

0

0

Protein kinase domain

PfMC-2TM

10

2

2

0

2

0

0

0

0

MC proteins

RIFIN

160

2

2

3

6

2

2

1

0

RBC surface proteins

STEVOR

30

2

2

0

0

0

0

0

0

MC proteins

a/b_HYDa

4

1 × 2, 2 × 1

1 × 1, 1 × 7, 2 × 2

0

0

0

0

0

0

a/b hydrolases

a/b_HYDb

4

0

2 × 1, 2 × 2

0

1

1

0

0

0

a/b hydrolases

HYP1

2

0

2

1

1

0

1

0

0

HYP2

3

1 × 2, 2 × 0

1 × 1, 2 × 2

0

0

0

0

0

0

Probably not a real family

PHISTa

23

0

2/3

2

1

2

2

1

1

Four alpha helices

PHISTb

23

0

2

13

10

6

6

2

3

Four alpha helices

PHISTc

16

0

2

9

4

2

7

1

0

Four alpha helices conserved

HYP4

8

1

2

0

0

0

0

0

0

Similar to HYP6

HYP5

7

1

2

0

0

0

0

0

0

HYP6

3

2

2

0

0

0

0

0

0

HYP7

3

2

2

0

0

0

0

0

0

Similar to HYP8

HYP8

2

2

2

2

1

0

2

0

0

Proteomics iRBC localisation

HYP9

5

1

2

1

2

0

0

0

0

HYP10

2

1

2

0

0

0

0

0

0

May be GPI anchored

HYP11

5

0

2 × 1, 3 × 2

0

1

0

0

0

0

Similar to PHIST

HYP12

3

0

2

2

1

1

1

0

0

HYP13

2

2

2

1

0

0

1

0

0

Similar to HYP5

HYP15

4

2

2 × 1, 2 × 2

0

0

0

1

0

0

Similar to HYP5

HYP16

2

1 × 1, 1 × 2

2

1

0

0

1

0

0

Conserved

HYP17

2

1

2

1

0

0

0

0

0


Approximately 75% of all 396 P. falciparum proteins predicted to be exported are organised in families. Counts in columns 5 to 10 represent the number of family members deemed to be expressed by this method for each life cycle stage (except PfEMP1). Abbreviations for life cycle stages in the microarray section are: R, ring; T, trophozoite; S, schizont; M, merozoite; Sp, sporozoite; G, gametocyte. GPI, glycosylphosphatidyl inositol; iRBC, infected red blood cell; MC, Maurer's clefts; RBC, red blood cell.

Sargeant et al. Genome Biology 2006 7:R12   doi:10.1186/gb-2006-7-2-r12

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