Table 1

Performance of our method with Escherichia coli orphan activities without independent sequence homology information

EC number

Description

Responsible gene

Rank

1.14.11.17

Taurine dioxygenase

b0368/tauD

1,143

1.1.1.251

Fructose 6-phosphate aldolase

b0825/fsa

1

1.1.1.264

L-idonate 5-dehydrogenase

b4267/idnD

44.5

1.2.1.22

Lactaldehyde dehydrogenase

b0356/adhC

1

1.2.1.22

Lactaldehyde dehydrogenase

b1241/adhE

18

1.2.1.22

Lactaldehyde dehydrogenase

b3588/aldB

208

1.2.1.22

Lactaldehyde dehydrogenase

b1415/aldA

654

1.2.2.2

Pyruvate oxidase

b0871/poxB

1,451

1.2.1.39

Phenylacetaldehyde dehydrogenase

b1385/feaB

1

1.1.1.57

Mannonate oxidoreductase

b4323/uxuB

71.5

1.1.1.77

Lacaldehyde reductase

b2799/fucO

10

2.7.1.130

Tetraacyldisaccharide 4'kinase

b0915/lpxK

1,507

2.6.1.66

Valine-pyruvate aminotransferase

b3572/avtA

70.5

2.7.1.58

2-Dehydro-3-deoxygalactonokinase

b3693/dgoK

68

2.7.1.73

Insosine kinase

b0477/gsk

1,041

3.2.2.4

AMP nucleosidase

b1982/amn

69

2.7.7.58

2,3-Dihydroxybenzoate adenylate synthase

b0594/entE

30

4.1.2.20

5-Dehydro-4-deoxyglucarate aldolase

b3126/garL

2,057.5

4.1.1.41

Methylmalonyl-CoA decarboxylase

b2919/ygfG

889

4.1.1.47

Glyoxalate carboligase

b0507/gcl

1

4.2.1.42

Galactarate dehydratase

b3128/garD

757

4.2.1.6

galactonate dehydratase

b3692/dgoA

1,841.5

4.2.1.7

Altronate hydrolase

b3091/uxaA

25

5.3.1.22

Hydroxypyruvate isomerase

b0508/hyi

33

6.2.1.30

Phenylacetate-CoA ligase

b1398/paaK

9

The subset of orphan activities, identified using the SWISS-PROT database [37], includes EC numbers with representative sequences exclusively from E. coli. We also included EC numbers with representative sequences in the TrEMBL database, but only if these were computationally annotated from E. coli sequences.

Chen and Vitkup Genome Biology 2006 7:R17   doi:10.1186/gb-2006-7-2-r17