Figure 7.

Regulation of PKA in committed cells. (a) The PKA pathway. The addition of glucose to a non-fermenting yeast culture results in a rapid increase in the cellular level of cyclic AMP (cAMP, red circle), which binds to the regulatory subunit of PKA, thereby releasing and activating the catalytic subunits. Arrows indicate activation and barred lines indicate inhibition. (b) BCY1 expression. (c,d) The average expression of PKA-responsive genes. The average is over (c) 161 PKA-induced and (d) 314 PKA-repressed genes (identified by [35]). Each expression pattern is accompanied by a colored bar indicating the log₂ fold change.