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TANGOing along the protein secretion pathway

Catherine Rabouille* and Vangelis Kondylis

Author Affiliations

University Medical Center Utrecht, The Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, Heidelberglaan 100, 3584CX Utrecht, The Netherlands

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Genome Biology 2006, 7:213  doi:10.1186/gb-2006-7-4-213

Published: 28 April 2006

Abstract

Although the organization and functions of the constitutive secretory pathway have been intensively studied for decades, a recent genome-wide RNAi screen in Drosophila cells has identified about 100 genes encoding novel so-called TANGO proteins (for transport and Golgi organization) that may be direct regulators of various aspects of protein exocytosis or secretion.