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Getting to synaptic complexes through systems biology

Bryen A Jordan1 and Edward B Ziff2*

Author Affiliations

1 Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA

2 Department of Biochemistry and Program in Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA

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Genome Biology 2006, 7:214  doi:10.1186/gb-2006-7-4-214

Published: 27 April 2006

Abstract

Large numbers of synaptic components have been identified, but the effect so far on our understanding of synaptic function is limited. Now, network maps and annotated functions of individual components have been used in a systems biology approach to analyzing the function of NMDA receptor complexes at synapses, identifying biologically relevant modular networks within the complex.