Genome Biology

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Benchmarking ortholog identification methods using functional genomics data

Tim Hulsen, Martijn A Huynen, Jacob de Vlieg and Peter MA Groenen*

Genome Biology 2006, 7:R31 doi:10.1186/gb-2006-7-4-r31

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BioMed Central: 17 citations

Proceedings   Open Access

ApicoAlign: an alignment and sequence search tool for apicomplexan proteins

Jamshaid Ali, Umadevi Paila, Akash Ranjan BMC Genomics 2011, 12(Suppl 3):S6 (30 November 2011)

Research   Open Access

Sequence variability of Rhizobiales orthologs and relationship with physico-chemical characteristics of proteins

Humberto Peralta, Gabriela Guerrero, Alejandro Aguilar, Jaime Mora Biology Direct 2011, 6:48 (4 October 2011)

Diversification of orthologous genes provokes specific physico-chemical changes in proteins of related species, revealing particular trends required to perform their functional roles in the adaptation to niche and intra-cellular conditions.

Research article   Open Access Highly Accessed

An integrative approach to ortholog prediction for disease-focused and other functional studies

Yanhui Hu, Ian Flockhart, Arunachalam Vinayagam, Clemens Bergwitz, Bonnie Berger, Norbert Perrimon, Stephanie E Mohr BMC Bioinformatics 2011, 12:357 (31 August 2011)

Research article   Open Access Highly Accessed

Mitochondrial genome deletions and minicircles are common in lice (Insecta: Phthiraptera)

Stephen L Cameron, Kazunori Yoshizawa, Atsushi Mizukoshi, Michael F Whiting, Kevin P Johnson BMC Genomics 2011, 12:394 (4 August 2011)

Mitochondrial genomes in several louse species form multiple, minicircular genomes each containing a subset of mitochondrial genes which may be due to loss of the mitochondrial single-stranded binding protein of the mtDNA replisome.

Correspondence   Free Highly Accessed

Joining forces in the quest for orthologs

Toni Gabaldón, Christophe Dessimoz, Julie Huxley-Jones, Albert J Vilella, Erik LL Sonnhammer, Suzanna Lewis Genome Biology 2009, 10:403 (29 September 2009)

Building momentum to coordinate and leverage community orthology prediction resources.

Research article   Open Access Highly Accessed

Evolutionary flexibility of protein complexes

Michael F Seidl, Jörg Schultz BMC Evolutionary Biology 2009, 9:155 (7 July 2009)

Software   Open Access Highly Accessed

EDGAR: A software framework for the comparative analysis of prokaryotic genomes

Jochen Blom, Stefan P Albaum, Daniel Doppmeier, Alfred Pühler, Frank-Jörg Vorhölter, Martha Zakrzewski, Alexander Goesmann BMC Bioinformatics 2009, 10:154 (20 May 2009)

Review   Free Highly Accessed

Large-scale assignment of orthology: back to phylogenetics?

Toni Gabaldón Genome Biology 2008, 9:235 (30 October 2008)

Automated use of phylogenetic trees to deduce orthology relationships in proteins.

Database   Open Access

Automatically extracting functionally equivalent proteins from SwissProt

Lisa EM McMillan, Andrew CR Martin BMC Bioinformatics 2008, 9:418 (6 October 2008)

Methodology article   Open Access Highly Accessed

Phylogenomics of plant genomes: a methodology for genome-wide searches for orthologs in plants

Matthieu G Conte, Sylvain Gaillard, Gaetan Droc, Christophe Perin BMC Genomics 2008, 9:183 (21 April 2008)

Research article   Open Access

Assessing the evolutionary rate of positional orthologous genes in prokaryotes using synteny data

Frédéric Lemoine, Olivier Lespinet, Bernard Labedan BMC Evolutionary Biology 2007, 7:237 (29 November 2007)

Research article   Open Access

Experimental-confirmation and functional-annotation of predicted proteins in the chicken genome

Teresia J Buza, Fiona M McCarthy, Shane C Burgess BMC Genomics 2007, 8:425 (19 November 2007)

Research   Open Access Highly Accessed

The human phylome

Jaime Huerta-Cepas, Hernán Dopazo, Joaquín Dopazo, Toni Gabaldón Genome Biology 2007, 8:R109 (13 June 2007)

The human phylome, which includes evolutionary relationships of all human proteins and their homologs among thirty-nine fully sequenced eukaryotes, is reconstructed.

Database   Open Access Highly Accessed

PlnTFDB: an integrative plant transcription factor database

Diego Riaño-Pachón, Slobodan Ruzicic, Ingo Dreyer, Bernd Mueller-Roeber BMC Bioinformatics 2007, 8:42 (7 February 2007)

Research article   Open Access Highly Accessed

Testing statistical significance scores of sequence comparison methods with structure similarity

Tim Hulsen, Jacob de Vlieg, Jack AM Leunissen, Peter MA Groenen BMC Bioinformatics 2006, 7:444 (12 October 2006)

Database   Open Access Highly Accessed

PhyloPat: phylogenetic pattern analysis of eukaryotic genes

Tim Hulsen, Jacob de Vlieg, Peter MA Groenen BMC Bioinformatics 2006, 7:398 (1 September 2006)