Figure 3.

Spontaneous conformational change in serpins. (a) Structure of native SERPINE1 (PDB code 1B3K) [96]. The RCL is in magenta and strand s1c of β-sheet C is in yellow. (b) The structure of latent SERPINE1 (PDB code 1DVN) [53,97], which can form by spontaneous conversion from the native protein. The RCL (magenta) is inserted into β-sheet A. In order to enable full insertion of the RCL, s1C of β-sheet C (pale yellow) has peeled off. In addition, conformational change in the strands s3C and s4C (pale green) is indicated. (c) Structure of SERPINE1 (blue) in complex with the somatomedin B domain (green) of vitronectin (PDB code 1OC0) [54]. The interaction with vitronectin locks SERPINE1 in the native, active conformation.

Law et al. Genome Biology 2006 7:216   doi:10.1186/gb-2006-7-5-216
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