Histone H4 lysine 16 acetylation breaks the genome's silence
1 Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
2 Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
Genome Biology 2006, 7:217 doi:10.1186/gb-2006-7-5-217Published: 10 May 2006
Acetylation at histone H4 lysine 16 is involved in many cellular processes in organisms as diverse as yeast and humans. A recent biochemical study pinpoints this particular acetylation mark as a switch for changing chromatin from a repressive to a transcriptionally active state.