RNA interference pinpoints regulators of cell size and the cell cycle
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* Corresponding author: Sally J Leevers sally.leevers@cancer.org.uk
1 Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
2 Growth Regulation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
Genome Biology 2006, 7:219 doi:10.1186/gb-2006-7-5-219
Published: 30 May 2006Abstract
Cell-based genome-wide RNA interference screens are being used to address an increasingly broad spectrum of biological questions. In one recent screen, Drosophila cell cultures treated with double-stranded RNA were analyzed by flow cytometry, providing a wealth of new information and identifying 488 regulators of the cell cycle, cell size, and cell death.