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Influence of metabolic network structure and function on enzyme evolution

Dennis Vitkup*, Peter Kharchenko and Andreas Wagner

Genome Biology 2006, 7:R39 doi:10.1186/gb-2006-7-5-r39

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Difference in the distribution pattern of substrate enzymes in the metabolic network of Escherichia coli, according to chaperonin requirement

Kazuhiro Takemoto, Tatsuya Niwa, Hideki Taguchi BMC Systems Biology 2011, 5:98 (24 June 2011)

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Evolutionary rate patterns of the Gibberellin pathway genes

Yan-hua Yang, Fu-min Zhang, Song Ge BMC Evolutionary Biology 2009, 9:206 (18 August 2009)

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Evolutionary rates and centrality in the yeast gene regulatory network

Richard Jovelin, Patrick C Phillips Genome Biology 2009, 10:R35 (9 April 2009)

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Yeast transcription factors that are more central in the transcription network tend to evolve more quickly.

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Network-based approaches for linking metabolism with environment

Sarath Janga, M Madan Babu Genome Biology 2008, 9:239 (24 November 2008)

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Genome-wide metabolic maps allow the development of network-based computational approaches for linking an organism with its biochemical habitat.

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Comparable contributions of structural-functional constraints and expression level to the rate of protein sequence evolution

Maxim Y Wolf, Yuri I Wolf, Eugene V Koonin Biology Direct 2008, 3:40 (7 October 2008)

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Investigations into the relationship between feedback loops and functional importance of a signal transduction network based on Boolean network modeling

Yung-Keun Kwon, Sun Choi, Kwang-Hyun Cho BMC Bioinformatics 2007, 8:384 (15 October 2007)

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Modular co-evolution of metabolic networks

Jing Zhao, Guo-Hui Ding, Lin Tao, Hong Yu, Zhong-Hao Yu, Jian-Hua Luo, Zhi-Wei Cao, Yi-Xue Li BMC Bioinformatics 2007, 8:311 (27 August 2007)

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Impacts of yeast metabolic network structure on enzyme evolution

Chenqi Lu, Ze Zhang, Lindsey Leach, MJ Kearsey, ZW Luo Genome Biology 2007, 8:407 (9 August 2007)

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Vitkup et al. recently presented an analysis of the influence of yeast metabolic network structure on enzyme evolution; different conclusions are reached when modularity is properly accounted for.

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Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia

Timothy Hughes, Diana Ekman, Himanshu Ardawatia, Arne Elofsson, David A Liberles Genome Biology 2007, 8:213 (22 May 2007)

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Can dosage compensation completely explain gene retention after whole-genome duplication?

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