Figure 1.

The correlation between enzyme connectivity and centrality in the yeast metabolic network. Spearman's rank correlation r = -0.74, P < 0.0001; Pearson's correlation r = -0.67, P < 0.0001. The centrality of an enzyme is equal to the mean length of network distances from the enzyme to all other enzymes in the networks (pairs of enzymes not connected by any path in the network were excluded from the calculation).