Figure 1.

Phylogenetic analysis of (a) MAP1 and (b) LC3 family proteins. LC3-related proteins do not share significant sequence homology with any of the MAP1 family members; phylogenetic relationships of the two families were therefore analyzed separately using Phylip [60]. Drosophila Futsch and the family members found by sequence analysis from the pufferfish Tetraodon nigroviridis cannot be definitively assigned as orthologs to any one mammalian protein.