|
Interaction partners of MAP1-family proteins |
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| Interacting protein* |
Proposed function of the interaction |
References |
|
|
|
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| MAP1A |
Microtubules |
Stabilization of microtubules |
[14,13,17] |
| F-actin |
Integration of microtubule and F-actin cytoskeletons |
[13] |
|
| EPAC |
Enhancement of Rap1 GTPase activity and cell adhesion |
[42] |
|
| DISC1 |
Linking of DISC1 to microtubules; pathogenesis of schizophrenia |
[43] |
|
| PSD-93 |
Linking of PSD-93 to microtubules |
[44] |
|
| CK1δ |
Interaction with and phosphorylation of the MAP1A light chain LC2 in vitro |
[45] |
|
| BKCa potassium channel |
Association of the channel with the cytoskeleton |
[46] |
|
| MAP1B |
Microtubules |
Stabilization of microtubules |
[13,15,16,47] |
| F-actin |
Integration of microtubule and F-actin cytoskeletons |
[13,18,48] |
|
| Mapmodulin |
Modulation of neurite extension |
[49] |
|
| Gigaxonin |
Enhanced stabilization of microtubules by MAP1B; control of MAP1B light chain degradation; potential role in giant axonal neuropathy |
[37,50] |
|
| Myelin-associated glycoprotein |
Enhanced MAP1B expression and phosphorylation |
[51] |
|
| GABA(C) receptor |
Linking of GABA(C) receptors to the cytoskeleton |
[52] |
|
| FMR1 |
Interaction with MAP1B mRNA and repression of its translation |
[53] |
|
| ee3 |
Alteration of the stability or folding of ee3 |
[54] |
|
| LIS1 |
Interference with the LIS1-dynein interaction |
[55] |
|
| GRIP1 |
Localization of AMPA receptors to synaptic sites |
[56] |
|
| LC3 |
Microtubules |
Regulation of the microtubule binding of MAP1A and MAP1B |
[6] |
| Caldendrin |
Transduction of calcium signals |
[57] |
|
| MAP1S |
Microtubules |
Stabilization of microtubules |
[4] |
| F-actin |
Integration of microtubule and F-actin cytoskeletons |
[4] |
|
| RASSF1A |
Regulation of mitotic progression |
[58,59] |
|
|
*Abbreviations: EPAC, exchange protein directly activated by cAMP; DISC1, disrupted-in-schizophrenia 1; PSD-93, postsynaptic density-93; CK1δ, casein kinase I delta; BKCa, large-conductance Ca2+-dependent K+ channel; GABA, gamma-aminobutyric acid; FMR1, Fragile X mental retardation 1; ee3, orphan G-protein coupled receptor; LIS1, lissencephaly-related protein 1; AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GRIP1, glutamate receptor interacting protein 1; RASSF1A, Ras association domain family 1A. | |||
Halpain and Dehmelt Genome Biology 2006 7:224 doi:10.1186/gb-2006-7-6-224 |
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