Figure 8.

Neighbors of proteins of low connectivity (white nodes), party hubs (green nodes) and date hubs (yellow nodes); an example. a) Non-hub protein PGM1 (YKL127W, large node) is the metabolic enzyme phosphoglucomutase, which consists of four well characterized domains associated with phosphoglucomutase activity. PGM1 is only connected to two other proteins, which are not hubs. b) Party hub protein CDC16 (YKL022C, large node) is an essential protein and is part of the anaphase-promoting complex (APC). It contains six tetratricopeptide domains, one additional Pfam-A domain, two Pfam-B domains and three orphan domains (blue rectangles). CDC16 interacts with party hubs, date hubs as well as two IC and NH proteins. c) Date hub protein NUP1 (YOR098C, large node) is a nuclear pore complex protein of diverse function which contains three Pfam-B domains, two orphan domains and one long disordered region (dashed). It interacts with other date hubs, party hubs and several non hub proteins. The network figures were drawn using BioLayout[52].