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Open Access Research

Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling

Daniel E Zak12, Haiping Hao1, Rajanikanth Vadigepalli1, Gregory M Miller12, Babatunde A Ogunnaike2 and James S Schwaber1*

Author Affiliations

1 Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Thomas Jefferson University, Locust St, Philadelphia, PA, USA 19107

2 Department of Chemical Engineering, University of Delaware, Academy St, Newark, DE, USA 19716

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Genome Biology 2006, 7:R48  doi:10.1186/gb-2006-7-6-r48

Published: 19 June 2006

Additional files

Additional data file 1:

Gene expression boxplots for several genes with specific circadian time dependent EGF responses in the SCN.

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Additional data file 2:

Gene expression boxplots for the transcription factors investigated by qRT-PCR.

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Additional data file 3:

P values for EGF effects and EGF:CT interactions for all genes present on the microarrays of the current study.

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Additional data file 4:

P values for EGF effects and EGF:CT interactions for SCN circadian genes [17] present on the microarrays of the current study.

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Additional data file 5:

Detailed materials and methods.

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Additional data file 6:

Additional results.

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