Old friends and new players. Genes differentially expressed in regulatory and naïve T cells, as identified by application of the Human TReg Chip. The upper half of the Venn diagram summarizes 'old friends'(namely, TReg cell associated genes that have previously been described in literature for either mouse or human). The lower half of the chart illustrates the new situation by showing all of the 'new players' of the TReg cell fingerprint. As demonstrated by the extended intersection, we identified eight genes, which formerly had only been implicated in mouse TReg cell immunology, as playing an additional role in human TRegcell activity (red arrow). Furthermore, our results expanded our knowledge on the transcriptional pattern characterizing human TReg cells by adding 41 new candidate genes (indicated by the red '+').
Pfoertner et al. Genome Biology 2006 7:R54 doi:10.1186/gb-2006-7-7-r54