Figure 6.

Functional dissection of signaling modules in human T_Reg cells. Schematic representation of potential signaling pathways involving genes that control (a) survival/apoptosis, and (b) TCR signaling/activation/proliferation and differentiation/maintenance of human regulatory T cells, thereby mediating T_Reg cell functionality. Transcriptional upregulation of genes in T_Reg versus naïve T cell is marked by red symbols, whereas green symbols represent downregulated genes. Symbols filled with grey depict unaffected genes or summarize pathway modules.