Functional dissection of signaling modules in human TReg cells. Schematic representation of potential signaling pathways involving genes that control (a) survival/apoptosis, and (b) TCR signaling/activation/proliferation and differentiation/maintenance of human regulatory T cells, thereby mediating TReg cell functionality. Transcriptional upregulation of genes in TReg versus naïve T cell is marked by red symbols, whereas green symbols represent downregulated genes. Symbols filled with grey depict unaffected genes or summarize pathway modules.
Pfoertner et al. Genome Biology 2006 7:R54 doi:10.1186/gb-2006-7-7-r54