Figure 7.

Network diagram of ThiS/MoaD-like β-grasp domains. The interaction network depicted here represents the known functional associations (arrows colored orange), the associations suggested by domain architectures (arrows colored green), and the associations suggested by gene neighborhood (arrows colored gray) between pairs of domains, as described in the text. The directionality of the network interactions, as indicated by an arrowhead, represents the order of a domain pair from the amino- to the carboxyl-terminus of the domain architecture or from the 5' to 3' end of a gene neighborhood. Lines with arrowheads at both ends represent domain pairs found both amino-terminal and carboxyl-terminal to each other in domain architectures or 5' to 3' in operonic contexts. The primary 'hubs' of the network are highlighted prominently. Domains are not exactly to scale. Selected interactions are encircled by small ellipses connected to the labels describing the functional role of the interaction. The labels are portrayed as large black ellipses with white lettering. MBL, metallo-β-lactamase domain; OAHS hyd, O-acetylhomoserine sulfhydrylase; PDOR, pyridine disulfide oxidoreductase; Rhod, Rhodanese-like domain; Toluene mono, toluene mono-oxygenase; ZnR, zinc-ribbon containing domain.