Co-evolution of transcription factors and their targets depends on mode of regulation

Ruth Hershberg and Hanah Margalit

Department of Molecular Genetics and Biotechnology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

author email corresponding author email

Genome Biology 2006, 7:R62doi:10.1186/gb-2006-7-7-r62


Published:	19 July 2006

Subject areas: Genome studies, Evolution, Microbiology and parasitology

Additional files

Additional data file 1:

Supplemetary Table 1 lists information regarding the 30 organisms used in the study. Supplementary Table 2 lists the association between the status of TFs and the status of their targets. Supplementary Figure 1 shows the probability of activators and repressors to be absent in the different genomes, while their targets are present. Supplementary Figure 2 shows the probability of repressed and activated targets to be absent from the different genomes, while their regulating TFs are present.

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Additional data file 2:

Regulatory interactions included in this study.

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Additional data file 3:

Classification of TFs into three groups based on their presence in the different organisms.

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