Genome Biology

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Analysis of cell-based RNAi screens

Michael Boutros*, Lígia P Brás and Wolfgang Huber*

Genome Biology 2006, 7:R66 doi:10.1186/gb-2006-7-7-r66

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BioMed Central: 10 citations

Research article   Open Access

Normalizing for individual cell population context in the analysis of high-content cellular screens

Bettina Knapp, Ilka Rebhan, Anil Kumar, Petr Matula, Narsis A Kiani, Marco Binder, Holger Erfle, Karl Rohr, Roland Eils, Ralf Bartenschlager, Lars Kaderali BMC Bioinformatics 2011, 12:485 (20 December 2011)

Methodology article   Open Access

Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi

Elin Axelsson, Thomas Sandmann, Thomas Horn, Michael Boutros, Wolfgang Huber , Bernd Fischer BMC Bioinformatics 2011, 12:342 (17 August 2011)

Software   Open Access Highly Accessed

Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities

Andrew N Tolopko, John P Sullivan, Sean D Erickson, David Wrobel, Su L Chiang, Katrina Rudnicki, Stewart Rudnicki, Jennifer Nale, Laura M Selfors, Dara Greenhouse, Jeremy L Muhlich, Caroline E Shamu BMC Bioinformatics 2010, 11:260 (18 May 2010)

Software   Open Access Highly Accessed

web cellHTS2: A web-application for the analysis of high-throughput screening data

Oliver Pelz, Moritz Gilsdorf, Michael Boutros BMC Bioinformatics 2010, 11:185 (12 April 2010)

Research article   Open Access Highly Accessed

Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis

Ian Sudbery, Anton J Enright, Andrew G Fraser, Ian Dunham BMC Genomics 2010, 11:175 (15 March 2010)

Research   Open Access

A global survey identifies novel upstream components of the Ath5 neurogenic network

Marcel Souren, Juan Martinez-Morales, Panagiota Makri, Beate Wittbrodt, Joachim Wittbrodt Genome Biology 2009, 10:R92 (7 September 2009)

Regulators of vertebrate Ath5 expression were identified by high-throughput screening; extending the current gene regulatory model network controlling retinal neurogenesis.

Research article   Open Access Highly Accessed

Knowledge based identification of essential signaling from genome-scale siRNA experiments

Armand Bankhead, Iliana Sach, Chester Ni, Nolwenn LeMeur, Mark Kruger, Marc Ferrer, Robert Gentleman, Carol Rohl BMC Systems Biology 2009, 3:80 (5 August 2009)

Research article   Open Access

A network-based integrative approach to prioritize reliable hits from multiple genome-wide RNAi screens in Drosophila

Li Wang, Zhidong Tu, Fengzhu Sun BMC Genomics 2009, 10:220 (12 May 2009)

Research   Open Access

PDGF/VEGF signaling controls cell size in Drosophila

David Sims, Peter Duchek, Buzz Baum Genome Biology 2009, 10:R20 (12 February 2009)

Pvr and its ligands, Pvf 2 and 3, which are upstream of Ras and PI3kinase, are identified from a genome-wide screen in Drosophila cells, as regulators of cell growth.

Software   Open Access Highly Accessed

CellProfiler Analyst: data exploration and analysis software for complex image-based screens

Thouis R Jones, In Kang, Douglas B Wheeler, Robert A Lindquist, Adam Papallo, David M Sabatini, Polina Golland, Anne E Carpenter BMC Bioinformatics 2008, 9:482 (15 November 2008)