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Unraveling the transcriptional network controlling ES cell pluripotency

Sridhar Rao1 and Stuart H Orkin12*

Author Affiliations

1 Division of Hematology-Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA

2 Harvard Stem Cell Institute and the Howard Hughes Medical Institute, 1 Blackfan Circle, Karp Research Building, Children's Hospital, Boston, MA 02115, USA

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Genome Biology 2006, 7:230  doi:10.1186/gb-2006-7-8-230

Published: 30 August 2006

Abstract

Embryonic stem cells (ES cells) are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate transcriptional pathways in ES cells for maintenance of the undifferentiated state and for self-renewal.