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Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi

Ola Snøve123 and John J Rossi1*

Author Affiliations

1 Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91101, USA

2 Interagon AS, Laboratoriesenteret, NO-7006 Trondheim, Norway

3 Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, NO-7006 Trondheim, Norway

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Genome Biology 2006, 7:231  doi:10.1186/gb-2006-7-8-231

Published: 29 August 2006

Abstract

Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?