Table 1

Accession numbers, chromosomal locations, and functions of PGRPs

*Vertebrate PGRPs were initially named PGRP-S, PGRP-L, and PGRP-Iα and PGRP-Iβ (for short, long, and intermediate transcripts). The human and mouse PGRPs have been renamed PGLYRP-1, PGLYRP-2, PGLYRP-3, and PGLYRP-4, respectively, and this new nomenclature is followed here for all vertebrate PGRP orthologs. Current nomenclature of D. melanogaster PGRP-LA, -LB, and -LC isoforms (-A, -B, and so on) is indicated. Previous names are also included, indicated by lower case letters in parentheses. For D. melanogaster PGRP-LD, isoforms -A, -B, and -C have the same amino-acid sequence, and only isoform A is shown. ^†Accession numbers starting with XM are predicted proteins. ^‡A dash in the PBD ID column indicates that a structure or function has not been determined. ^§Amidase activities were predicted on the basis of the presence of all four Zn²⁺-binding amino acids and other amino acids required for the amidase activity, as described [9,14,15]. PPO, prophenol-oxidase. ^¶D. melanogaster PGRP-SC1a and PGRP-SC1b are encoded by two adjacent genes translated into proteins with identical amino acid sequences. ^¥Bactericidal activities were predicted on the basis of homology to human PGLYRPs.

Dziarski and Gupta Genome Biology 2006 7:232   doi:10.1186/gb-2006-7-8-232