Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution
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* Corresponding author: Andrew G Fraser agf@sanger.ac.uk
Genome Biology 2006, 7:R69 doi:10.1186/gb-2006-7-8-r69
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Methodology article
Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi Elin Axelsson, Thomas Sandmann, Thomas Horn, Michael Boutros, Wolfgang Huber , Bernd Fischer BMC Bioinformatics 2011, 12:342 (17 August 2011) |
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Research article
Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation Kevin Hannay, Edward M Marcotte, Christine Vogel BMC Genomics 2008, 9:609 (16 December 2008) Gene duplication does contribute to the robustness of organisms against disruption of gene function but it appears to have a smaller effect than might be expected across a range of organisms, particularly in some eukaryotes.
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Research
Igor B Rogozin, Karen Thomson, Miklós Csürös, Liran Carmel, Eugene V Koonin Biology Direct 2008, 3:7 (17 March 2008) Homoplasy denotes the same (parallel) mutations occurring independently in different lineages. It is a scourge of phylogenetic methods. Here, however, it is shown that homoplasy is also an interesting evolutionary phenomenon. Homplasy seems, at least, in part, to underlie the so-called homologous series of phenotypic variation occurring in different, particularly, closely related lineages, an effect first described by the famous Russian geneticict Vavilov some 90 years ago.
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Minireview
A Caenorhabditis elegans genetic-interaction map wiggles into view Kristin C Gunsalus Journal of Biology 2008, 7:8 (7 March 2008) |
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Research
Comparative analysis indicates regulatory neofunctionalization of yeast duplicates Itay Tirosh, Naama Barkai Genome Biology 2007, 8:R50 (5 April 2007) Comparison of the expression profiles of |
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Methodology article
Najaf A Shah, Richard J Laws, Bradley Wardman, Lue Zhao, John L Hartman BMC Systems Biology 2007, 1:3 (8 January 2007) Automated image analysis of yeast on agar culture arrays provides accurate data on yeast culture biomass, allowing robust quantitative modeling of yeast cell proliferation.
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