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Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution

Julia Tischler1, Ben Lehner12, Nansheng Chen3 and Andrew G Fraser1*

Author Affiliations

1 The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK

2 CRG-EMBL Systems Biology Program, Centre for Genomic Regulation, Barcelona, Spain

3 Molecular Biology and Biochemistry, Simon Fraser University, University Drive, Burnaby, British Columbia, V5A 1S6, Canada

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Genome Biology 2006, 7:R69  doi:10.1186/gb-2006-7-8-r69

Published: 2 August 2006

Additional files

Additional data file 1:

A Word document listing C. elegans chromosome III genes with a previously assigned nonviable (embryonic lethal or sterile) RNAi phenotype [2] and the effect of dilution following combinatorial RNAi.

Format: DOC Size: 234KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional data file 2:

A Word document listing C. elegans pairs of duplicated genes that have been screened for synthetic RNAi phenotypes.

Format: DOC Size: 193KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional data file 3:

A Word document listing C. elegans 1:1 orthologs of S. cerevisiae genes and their RNAi phenotypes.

Format: DOC Size: 587KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional data file 4:

A Word document presenting C. elegans duplicate gene pairs included in this study, their orthologous genes in C. briggsae, and levels of protein identity between C. elegans gene duplicates, as well as Ka and Ks values between duplicate gene pairs.

Format: DOC Size: 243KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data