Table 4

C. elegans duplicate gene pairs with at least partially redundant functions

Interaction Gene1 + Gene2

Gene1

Gene2

Gene1 + 2

p value


BS

ES

BS

ES

BS

ES

BS

ES


pab-1 + pab-2

15

100

88

100

0

ns

1.9 × 10-04

ns

rpl-25.2 + rpl-25.1

6

50

17

63

0

ns

3.6 × 10-04

ns

ptr-2 + ptr-10

a

53

a

98

a

ns

a

ns

unc-78 + tag-216

85

96

98

97

0

ns

6.4 × 10-15

ns

rab-8 + rab-10

87

98

70

96

1

ns

7.3 × 10-05

ns

B0495.2 + ZC504.3

84

99

97

99

2

55

6.3 × 10-09

2.9 × 10-03

rpa-2 + C37A2.7

67

74

50

81

1

ns

1.9 × 10-07

ns

C28H8.4 + erd-2

93

95

86

94

10

10

5.6 × 10-08

2.2 × 10-15

lin-12 + glp-1

90

88

99

83

16

75

1.2 × 10-13

7.3 × 10-01

C13G3.3 + W08G11.4

73

94

80

97

17

89

1.6 × 10-06

3.5 × 10-01

lin-53 + rba-1

74

63

48

5

16

75

1.1 × 10-02

7.3 × 10-17

Y53C12A.4 + R02E12.2

84

81

78

87

32

75

1.3 × 10-03

6.9 × 10-01

F37C12.7 + acs-17

95

100

77

98

44

73

9.4 × 10-03

4.2 × 10-06

C05G5.4 + F23H11.3

96

100

94

98

58

72

5.1 × 10-06

1.5 × 10-08

elt-6 + egl-18

100

97

82

88

63

73

4.0 × 10-02

6.3 × 10-03

dsh-1 + dsh-2

97

98

75

54

58

17

1.6 × 10-02

1.1 × 10-11


C. elegans duplicate gene pairs (Interaction Gene1 + Gene2) displaying synthetic phenotypic effects upon combinatorial RNA interference (RNAi) in the RNAi-hypersensitive strain rrf-3 [19] are listed. Numbers shown are percentages of average wild-type brood size (BS) and embryonic survival (ES) rates for each gene individually (Gene1 or Gene2) as well as for duplicate gene pairs (Gene1 + 2), and are the arithmetic mean of two independent biological repeats. p values were assigned using a Student's t-test. aNote that combinatorial RNAi against the duplicate gene pair ptr-2 + ptr-10 resulted in an increased number of first generation larval growth arrested worms, rather than in reduced brood size; fraction of population which is wild-type (does not arrest at an early larval stage): 70% (ptr-2), 100% (ptr-10), 0% (ptr-2 + ptr-10), p = 7.4 × 10-09. ns, given phenotype could not be scored.

Tischler et al. Genome Biology 2006 7:R69   doi:10.1186/gb-2006-7-8-r69

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