Table 4 |
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|
C. elegans duplicate gene pairs with at least partially redundant functions |
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|
Interaction Gene1 + Gene2 |
Gene1 |
Gene2 |
Gene1 + 2 |
p value |
||||
|
|
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|
BS |
ES |
BS |
ES |
BS |
ES |
BS |
ES |
|
|
|
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|
pab-1 + pab-2 |
15 |
100 |
88 |
100 |
0 |
ns |
1.9 × 10-04 |
ns |
|
rpl-25.2 + rpl-25.1 |
6 |
50 |
17 |
63 |
0 |
ns |
3.6 × 10-04 |
ns |
|
ptr-2 + ptr-10 |
a |
53 |
a |
98 |
a |
ns |
a |
ns |
|
unc-78 + tag-216 |
85 |
96 |
98 |
97 |
0 |
ns |
6.4 × 10-15 |
ns |
|
rab-8 + rab-10 |
87 |
98 |
70 |
96 |
1 |
ns |
7.3 × 10-05 |
ns |
|
B0495.2 + ZC504.3 |
84 |
99 |
97 |
99 |
2 |
55 |
6.3 × 10-09 |
2.9 × 10-03 |
|
rpa-2 + C37A2.7 |
67 |
74 |
50 |
81 |
1 |
ns |
1.9 × 10-07 |
ns |
|
C28H8.4 + erd-2 |
93 |
95 |
86 |
94 |
10 |
10 |
5.6 × 10-08 |
2.2 × 10-15 |
|
lin-12 + glp-1 |
90 |
88 |
99 |
83 |
16 |
75 |
1.2 × 10-13 |
7.3 × 10-01 |
|
C13G3.3 + W08G11.4 |
73 |
94 |
80 |
97 |
17 |
89 |
1.6 × 10-06 |
3.5 × 10-01 |
|
lin-53 + rba-1 |
74 |
63 |
48 |
5 |
16 |
75 |
1.1 × 10-02 |
7.3 × 10-17 |
|
Y53C12A.4 + R02E12.2 |
84 |
81 |
78 |
87 |
32 |
75 |
1.3 × 10-03 |
6.9 × 10-01 |
|
F37C12.7 + acs-17 |
95 |
100 |
77 |
98 |
44 |
73 |
9.4 × 10-03 |
4.2 × 10-06 |
|
C05G5.4 + F23H11.3 |
96 |
100 |
94 |
98 |
58 |
72 |
5.1 × 10-06 |
1.5 × 10-08 |
|
elt-6 + egl-18 |
100 |
97 |
82 |
88 |
63 |
73 |
4.0 × 10-02 |
6.3 × 10-03 |
|
dsh-1 + dsh-2 |
97 |
98 |
75 |
54 |
58 |
17 |
1.6 × 10-02 |
1.1 × 10-11 |
|
|
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|
C. elegans duplicate gene pairs (Interaction Gene1 + Gene2) displaying synthetic phenotypic effects upon combinatorial RNA interference (RNAi) in the RNAi-hypersensitive strain rrf-3 [19] are listed. Numbers shown are percentages of average wild-type brood size (BS) and embryonic survival (ES) rates for each gene individually (Gene1 or Gene2) as well as for duplicate gene pairs (Gene1 + 2), and are the arithmetic mean of two independent biological repeats. p values were assigned using a Student's t-test. aNote that combinatorial RNAi against the duplicate gene pair ptr-2 + ptr-10 resulted in an increased number of first generation larval growth arrested worms, rather than in reduced brood size; fraction of population which is wild-type (does not arrest at an early larval stage): 70% (ptr-2), 100% (ptr-10), 0% (ptr-2 + ptr-10), p = 7.4 × 10-09. ns, given phenotype could not be scored. |
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|
Tischler et al. Genome Biology 2006 7:R69 doi:10.1186/gb-2006-7-8-r69 |
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