Table 5

Molecular functions of C. elegans duplicate gene pairs with synthetic phenotypes

Duplicate gene pair

NCBI KOGs


pab-1 + pab-2

Polyadenylate-binding protein (RRM superfamily)

rpl-25.2 + rpl-25.1

60s ribosomal protein L23

ptr-2 + ptr-10

Predicted membrane protein (patched superfamily)

unc-78 + tag-216

WD40 repeat stress protein/actin interacting protein

rab-8 + rab-10

GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins

B0495.2 + ZC504.3

Protein kinase PITSLRE and related kinases

rpa-2 + C37A2.7

60S acidic ribosomal protein P2

C28H8.4 + erd-2

ER lumen protein retaining receptor

lin-12 + glp-1

Member of the Notch/LIN-12/glp-1 transmembrane receptor familya

C13G3.3 + W08G11.4

Serine/threonine protein phosphatase 2A, regulatory subunit

lin-53 + rba-1

Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1

Y53C12A.4 + R02E12.2

Conserved protein Mo25

F37C12.7 + acs-17

Acyl-CoA synthetase

C05G5.4 + F23H11.3

Succinyl-CoA synthetase, alpha subunit

elt-6 + egl-18

GATA-4/5/6 transcription factors

dsh-1 + dsh-2

Dishevelled 3 and related proteins


NCBI eukaryotic orthologous groups (KOGs) [37] are listed for duplicate gene pairs with synthetic phenotypic effects upon combinatorial RNA interference (RNAi). aNote that WormBase gene descriptions are used for the duplicate gene pair lin-12 + glp-1.

Tischler et al. Genome Biology 2006 7:R69   doi:10.1186/gb-2006-7-8-r69

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