Table 5 |
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Molecular functions of C. elegans duplicate gene pairs with synthetic phenotypes |
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|
Duplicate gene pair |
NCBI KOGs |
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|
|
|
pab-1 + pab-2 |
Polyadenylate-binding protein (RRM superfamily) |
|
rpl-25.2 + rpl-25.1 |
60s ribosomal protein L23 |
|
ptr-2 + ptr-10 |
Predicted membrane protein (patched superfamily) |
|
unc-78 + tag-216 |
WD40 repeat stress protein/actin interacting protein |
|
rab-8 + rab-10 |
GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins |
|
B0495.2 + ZC504.3 |
Protein kinase PITSLRE and related kinases |
|
rpa-2 + C37A2.7 |
60S acidic ribosomal protein P2 |
|
C28H8.4 + erd-2 |
ER lumen protein retaining receptor |
|
lin-12 + glp-1 |
Member of the Notch/LIN-12/glp-1 transmembrane receptor familya |
|
C13G3.3 + W08G11.4 |
Serine/threonine protein phosphatase 2A, regulatory subunit |
|
lin-53 + rba-1 |
Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 |
|
Y53C12A.4 + R02E12.2 |
Conserved protein Mo25 |
|
F37C12.7 + acs-17 |
Acyl-CoA synthetase |
|
C05G5.4 + F23H11.3 |
Succinyl-CoA synthetase, alpha subunit |
|
elt-6 + egl-18 |
GATA-4/5/6 transcription factors |
|
dsh-1 + dsh-2 |
Dishevelled 3 and related proteins |
|
|
|
|
NCBI eukaryotic orthologous groups (KOGs) [37] are listed for duplicate gene pairs with synthetic phenotypic effects upon combinatorial RNA interference (RNAi). aNote that WormBase gene descriptions are used for the duplicate gene pair lin-12 + glp-1. |
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Tischler et al. Genome Biology 2006 7:R69 doi:10.1186/gb-2006-7-8-r69 |
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