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Hydrolases identified in tear fluid |
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| Hydrolase activity |
Gene symbol |
Biological process |
|
|
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| Leukotriene A-4 hydrolase |
LTA4H |
1,2 |
| Matrix metalloproteinase 8* |
MMP8 |
1,3 |
| Matrix metalloproteinase 9* |
MMP9 |
1,3 |
| Myeloblastin† |
PRTN3 |
3 |
| Apolipoprotein B |
APOBEC3C |
4 |
| Azurocidin† |
AZU1 |
4 |
| Dipeptidylpeptidase IV |
DPP4 |
4 |
| Leukocyte elastase* |
ELA2 |
4 |
| Haptoglobin* |
HP |
4 |
| Lactotransferrin* |
LTF |
4,5 |
| Lysozyme C* |
LYZ |
4 |
| Eosinophil cationic protein* |
RNASE3 |
4,9 |
| Adipocyte-derived leucine aminopeptidase† |
ARTS-1 |
5 |
| Zinc-alpha-2-glycoprotein* |
AZGP1 |
5 |
| Complement factor B† |
BF |
5 |
| Ubiquitin thiolesterase protein† |
OTUB1 |
5 |
| Palmitoyl-protein thioesterase 1 |
PPT1 |
6 |
| Plasminogen* |
PLG |
7 |
| Aminopeptidase N |
ANPEP |
8 |
| Acid phosphatase, prostate† |
ACPP |
10 |
| Chitinase 3-like protein 2† |
CHI3L2 |
11 |
| Cytosolic nonspecific dipeptidase† |
CNDP2 |
1 |
| Cathepsin B* |
CTSB |
1 |
| Cathepsin D |
CTSD |
1 |
| Cathepsin G |
CTSG |
1 |
| Cathepsin Z |
CTSZ |
1 |
| Prostasin† |
PRSS8 |
1 |
| Aminopeptidase B† |
RNPEP |
1 |
| Tissue alpha-L-fucosidase |
FUCA1 |
12 |
| Beta-mannosidase* |
MANBA |
13 |
| Alpha-N-acetylglucosaminidase* |
NAGLU |
12 |
| Neuraminidase |
NEU1 |
12 |
|
*The protein has already described in the tear fluid. †The protein is classified as an extracellular protein. 1, Proteolysis; 2, inflammatory response; 3, extracellular matrix degradation; 4, defense response; 5, immune response; 6, visual perception; 7, blood coagulation; 8, angiogenesis; 9, nucleotide metabolism; 10, regulation of cell proliferation; 11, chitin catabolism; 12, carbohydrate metabolism; 13, protein modification; 14, central nervous system development; 15, signal transduction. | ||
de Souza et al. Genome Biology 2006 7:R72 doi:10.1186/gb-2006-7-8-r72 |
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