Table 2

Protease inhibitors identified in the tear fluid

Protease inhibitor

Gene symbol

Biological process

Alpha-2-macroglobulin*

A2M

Alpha-2-HS-glycoprotein*

AHSG

2

Alpha-1-microglobulin^†

AMBP

2

Annexin 5

ANXA5

7

Complement C3*

C3

2,5

Complement C4^†

C4A

2,5

Cystatin B

CSTB

Cystatin SN*

CST1

Cystatin SA*

CST2

Cystatin C*

CST3

Cystatin S*

CST4

Inter-alpha-trypsin inhibitor heavy chain H1*

ITIH1

5

Inter-alpha-trypsin inhibitor heavy chain H2^†

ITIH2

5

Inter-alpha-trypsin inhibitor heavy chain H4^†

ITIH4

5

Lipocalin 1*

LCN1

5

Similar to Lipocalin 1

Lipocalin 2

LCN2

Latexin^†

LXN

Prosaposin^†

PSAP

Alpha-1-antitrypsin*

SERPINA1

5

Alpha-1-antichymotrypsin*

SERPINA3

2,5

Leukocyte elastase inhibitor*

SERPINB1

5

Plasminogen activator inhibitor-2^†

SERPINB2

7

Maspin^†

SERPINB5

Placental thrombin inhibitor^†

SERPINB6

Antithrombin-III^†

SERPINC1

7

Pigment epithelium-derived factor*

SERPINF1

8

Plasma protease C1 inhibitor^†

SERPING1

5,7

Neuroserpin

SERPINI1

14

Stratifin^†

SFN

15

Thrombospondin-1^†

THBS1

7

Tissue inhibitor of metalloproteinase 1*

TIMP1

10

*The protein has already described in the tear fluid. ^†The protein is classified as an extracellular protein. 1, Proteolysis; 2, inflammatory response; 3, extracellular matrix degradation; 4, defense response; 5, immune response; 6, visual perception; 7, blood coagulation; 8, angiogenesis; 9, nucleotide metabolism; 10, regulation of cell proliferation; 11, chitin catabolism; 12, carbohydrate metabolism; 13, protein modification; 14, central nervous system development; 15, signal transduction.

de Souza et al. Genome Biology 2006 7:R72   doi:10.1186/gb-2006-7-8-r72